U24

ALTERNATE NAMES: snR24

LENGTH: 89 nts

PROCESS: 2'-O-methylation of rRNA

TARGET SITE(S):
25S rRNA: Cm1437, Am1449, Gm1450

Guide Domains
 
Details of the guides at the Lowe Lab S. cerevisiae Methylation Guide snoRNA Database.
  Click number to see the target site in the 2D structure: 25S-1437, 25S-1449,25S-1450
Click number to see the approximate location of the modification site in the ribosome:25S-1437, 25S-1449,25S-1450

GENOMIC ORGANIZATION: Intronic snoRNA
 

SGD ORF MAP
ORFmap

GENE DISRUPTION PHENOTYPE: Viable

CORRESPONDENCES IN HUMANS AND PLANTS:
Click here and see that yeast and humans have corresponding modifications and guide snoRNAs.
Click here and see that yeast and Arabidopsis have corresponding modifications and guide snoRNAs.

PHYLOGENETIC CONSERVATION IN FUNGI:
Click here to examine conservation of the snoRNA in fungal genomes using BLAST.

RNA SEQUENCE:

  1 ucaaaugaug uaauaacaua uuugcuacuu cagauggaac uuugaguucc gaaugagaca
 61 uaccaauuau caccaagauc ucugaugaa
 

YEAST GENOME DATABASE ENTRY:
Click here to view the SGD entry for this snoRNA.

REFERENCES:
Qu, L. H., Y. Henry, M. Nicoloso, B. Michot, M. C. Azum, M. H. Renalier, M. Caizergues-Ferrer, and J. P. Bachellerie. 1995. U24, a novel intron-encoded small nucleolar RNA with two 12 nt long, phylogenetically conserved complementarities to 28S rRNA. Nucleic Acids Res. 23:2669-2676.
Kiss-Laszlo, Z., Y. Henry, J. P. Bachellerie, M. Caizergues-Ferrer, and T. Kiss. 1996. Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs. Cell 85:1077-1088.
Ni, J., and M. J. Fournier. (unpublished). In regards to information about gene disruption phenotype.
Last update: September 19, 2007 4:34 PM.