U18

ALTERNATE NAMES: snR18

LENGTH: 102 nts

PROCESS: 2'-O-methylation of rRNA

TARGET SITE(S):
25S rRNA: Am649, Am650

Guide Domains
 
Details of the guides at the Lowe Lab S. cerevisiae Methylation Guide snoRNA Database.
  Click number to see the target site in the 2D structure: 25S-649, 25S-650
Click number to see the approximate location of the modification site in the ribosome:25S-649, 25S-650

GENOMIC ORGANIZATION: Intronic snoRNA
 

SGD ORF MAP
ORFmap

GENE DISRUPTION PHENOTYPE: Viable

CORRESPONDENCES IN HUMANS AND PLANTS:
Click here and see that yeast and humans have corresponding modifications and guide snoRNAs.
Click here and see that yeast and Arabidopsis have corresponding modifications and guide snoRNAs.

PHYLOGENETIC CONSERVATION IN FUNGI:
Click here to examine conservation of the snoRNA in fungal genomes using BLAST.

RNA SEQUENCE:

   1 gugaaugaug aauuuaauuc uuugguccgu guuuaugaug ggaaguaaga cccccgauau
  61 gagugacaaa agagaugugg uugacuauca caguaucuga cg

YEAST GENOME DATABASE ENTRY:
Click here to view the SGD entry for this snoRNA.

REFERENCES:
Balakin, A. G., L. Smith, and M. J. Fournier. 1996. The RNA world of the nucleolus: two major families of small RNAs defined by different box elements with related functions. Cell 86:823-834.
Balakin, A. G., J. Ni, and M. J. Fournier. (unpublished). In regards to 2'-O-methylation of rRNA.
Wu, P., J. S. Brockenbrough, A. C. Metcalfe, S. Chen, and J. P. Aris. 1998. Nop5p is a small nucleolar ribonucleoprotein component required for pre-18S rRNA processing in yeast. J. Biol. Chem. 273:16453-16463.


Last update: October 13, 2006 8:03 AM.