snR81

ALTERNATE NAMES: None reported

LENGTH: 188 nts

PROCESS: Pseudouridine formation in rRNA and snRNA

TARGET SITE(S):
U2 snRNA: Y42
25S rRNA: Y1052
Guide Domains
  Click number to see the target site in the 2D structure of U2 snRNA: U2-42
Click number to see the to see the target site in the 2D structure of 25S rRNA: 25S-1052
Click number to see the approximate location of the modification site in the ribosome: 25S-1052

GENOMIC ORGANIZATION: Independent gene
 

SGD ORF MAP
ORFmap

GENE DISRUPTION PHENOTYPE: Viable

CORRESPONDENCES IN HUMANS AND PLANTS:
Click here and see that yeast and humans have corresponding modifications and guide snoRNAs.
 
None reported in plants

PHYLOGENETIC CONSERVATION IN FUNGI:
Schizosaccharomyces pombe has an orthologous snoRNA (although not noted in the paper originally, snR81 is a functional homolog of pombe snR93).

Click here to examine conservation of the snoRNA in fungal genomes using BLAST.

RNA SEQUENCE:

  1 agguuaggga cugcaaaaga agcggcgagg cagcccacau caaguggaac uacacagacu
 61 uccuugucgc gauacuacgg ucccaagagc aauccuaaca agcaauuaca uauucccccg
121 cugaaccugu acaguccacg gauggugcag aaguuauaug auuuggggga agacgcuuuu
181 ucacaucu
 

YEAST GENOME DATABASE ENTRY:
Click here to view the SGD entry for this snoRNA.

REFERENCES:
Schattner, P., W. A. Decatur, C. A. Davis, M. Ares, Jr., M. J. Fournier, and T. M. Lowe. 2004. Genome-wide searching for pseudouridylation guide snoRNAs: analysis of the Saccharomyces cerevisiae genome. Nucleic Acids Res. 32:4281-4296.
Torchet, C., G. Badis, F. Devaux, G. Costanzo, M. Werner, and A. Jacquier. 2005. The complete set of H/ACA snoRNAs that guide rRNA pseudouridylations in Saccharomyces cerevisiae. RNA 11:928-938.
Ma, X., C. Yang, A. Alexandrov, E. J. Grayhack, I. Behm-Ansmant, and Y. T. Yu. 2005. Pseudouridylation of yeast U2 snRNA is catalyzed by either an RNA-guided or RNA-independent mechanism. EMBO J. 24:2403-2413.
Last update: MArch 21, 2007 1:39 PM.