snR39

ALTERNATE NAMES: None reported

LENGTH: 89 nts

PROCESS: 2'-O-methylation of rRNA

TARGET SITE(S):
25S rRNA: Am807

Guide Domains
 
Details of the guide at the Lowe Lab S. cerevisiae Methylation Guide snoRNA Database.
  Click number to see the target site in the 2D structure: 25S-807
Click number to see the approximate location of the modification site in the ribosome: 25S-807

GENOMIC ORGANIZATION: Intronic snoRNA
 

SGD ORF MAP
ORFmap

GENE DISRUPTION PHENOTYPE: Viable

CORRESPONDENCES IN HUMANS AND PLANTS:
Click here and see that yeast and humans have corresponding modifications and guide snoRNAs.
Click here and see that yeast and Arabidopsis have corresponding modifications and guide snoRNAs.

PHYLOGENETIC CONSERVATION IN FUNGI:
Click here to examine conservation of the snoRNA in fungal genomes using BLAST.

RNA SEQUENCE:

   1 uuuuaugaug aaaauccauu guaucccaau acauauucga cuagucauug acgaugcugu
  61 cguaacuuau caccaucuuu cgacugauu

YEAST GENOME DATABASE ENTRY:
Click here to view the SGD entry for this snoRNA.

REFERENCES:
Bachellerie, J. P., B. Michot, M. Nicoloso, A. Balakin, J. Ni, and M. J. Fournier. 1995. Antisense snoRNAs: a family of nucleolar RNAs with long complementarities to rRNA. Trends Biochem. Sci. 20:261-264.
Kiss-Laszlo, Z., Y. Henry, J. P. Bachellerie, M. Caizergues-Ferrer, and T. Kiss. 1996. Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs. Cell 85:1077-1088.
Ni, J., and M. J. Fournier. (unpublished). In regards to 2'-O-methylation of rRNA.
Nicoloso, M., L. H. Qu, B. Michot, and J. P. Bachellerie. 1996. Intron-encoded, antisense small nucleolar RNAs: the characterization of nine novel species points to their direct role as guides for the 2'-O-ribose methylation of rRNAs. J. Mol. Biol. 260:178-195.
Ghazal, G., D. Ge, J. Gervais-Bird, J. Gagnon, and S. Abou Elela. 2005. Genome-wide prediction and analysis of yeast RNase III-dependent snoRNA processing signals. Mol. Cell. Biol. 25:2981-2994.


Last update: October 13, 2006 6:20 AM.