1971-75 B.S., Biology and Chemistry, University of Hartford, W. Hartford, CT.
1975-80 Ph.D., Molecular Biology, University of Connecticut Health Center, Farmington, CT Dr. Thomas E. Shenk, Advisor
1980-82 Postdoctoral Fellow, University of California, Santa Barbara, CA Dr. John A. Carbon, Sponsor
1982-94 Assistant and Associate Professor, Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA
1989-92 Associate Director, Graduate Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, MA
9/96-1/97 Co-Director, Graduate Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, MA
1994-2000 Professor, Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA
UMass Center for Teaching Award 2000-01
TEACHnology Award 2000-01
Nominated for University Distinguished Teaching Award, UMass, 1998
Mentor, Lilly Teaching Fellows Program, 1993-94
Elected Fellow, American Association for the Advancement of Science, 1990
National Institutes of Health Research Career Development Award, 1989-94
National Science Foundation Career Advancement Award, 1988-89
Founder and Co-Director, New England BioLabs Summer Workshops in Molecular Biology and Biotechnology, Smith College 1986-92, Paris, France 1987-88
Co-Director, UMass Summer Workshop in Molecular Biology and Biotechnology, 1986
Co-Director, Carolina Molecular Genetics Workshop, University of North Carolina, 1985
Molecular Cellular Biology Visiting Speakers Program, Southeastern Mass. Univ., 1984
Elected Member, American Society of Biological Chemists, 1983, Sigma Xi, 1983-84
Damon Runyon-Walter Winchell Postdoctoral Fellowship, 1980-82 (Supervisor: Dr. John A. Carbon)
Connecticut Research Foundation Doctoral Dissertation Fellowship, 1979-80
Connecticut Research Found. Travel Award; Tumor Virus Meeting, England, 1979
University of Connecticut Health Center Fellowship, 1975-79
Univ.of Hartford Scholarship, 1972-75
Dana Science Scholarship, 1972-75
Alpha Chi National Honor Scholarship Society, 1975
Dr. Joseph Wenograd Research Grant, 1974
1980-82 Damon Runyon Cancer Research Foundation, $32,000
1988-89 NSF Career Advancement Award (DBM-8809121), "Analysis of Centromere-Specific Genes in Yeast", $51,392 (total costs) M. Fitzgerald-Hayes, P.I.
1983-94 NIH (RO1 GM32257) "Yeast Centromere Structure and Function", $1,170,000 (total direct costs) M. Fitzgerald-Hayes, P.I.
1990-94 NIH (K04 GM00528) Research Career Development Award, "Analysis of Components Involved in Centromere Function", $300,000 (total costs) M. Fitzgerald-Hayes, P.I.
1994-96 Healey Endowment Grant, "Genetic Studies on the Chromosome Segregation Protein, Cse4p", $5,000 (total costs) M. Fitzgerald-Hayes, P.I.
1996-97 Faculty Research Grant, "Mutations Affecting Binding of Cse4p to H4", $5,000 (total costs) M. Fitzgerald-Hayes, P.I.
1996-2004 NIH (RO1 GM54766) "Functional Analysis of Centromeric Chromatin in Yeast", $1,259,513 (Direct costs) M. Fitzgerald-Hayes, P.I.
ASBC Symposium on Chromosome Structure and Gene Function, 1983
Gordon Conference on Extrachromosomal Elements, 1983 (cited in Science News, 124:12; 1983)
Gordon Conference on Biological Regulatory Mechanisms, 1984
Natíl Meeting of the Am. Society of Microbiology, Symposium on Chromosome Structure, 1988
Gordon Conference on Extrachromosomal Elements, 1989
FASEB Summer Conference on Chromosome Replication and Segregation,1990
NATO International Workshop on Chromosome Segregation & Aneuploidy, Greece, 1992
FASEB Conference on Chromosome Replication and Segregation in Yeast, Platform Session Chair: Mutational Analysis of Chromosome Stability, 1992
GSA Conference Yeast Genetics and Mol. Bio. Session Chair: Chrom. Structure and Dynamics, 1993
Gordon Conference on Segregation Elements, 1995
FASEB Conference on Chromosome Replication and Segregation in Yeast, Organizing Committee Chair, 1994, Session Chair, 1996, Invited Speaker, 1998
Gordon Conference on Plasmid and Chromosome Dynamics, Summer 1999
Fitzgerald, M. and T. Shenk. The
site at which late mRNAs are polyadenylated is altered in SV40 mutant
dl882. N.Y. Academy of
Sciences 354: 53-59 (1980).
Fitzgerald, M. and T. Shenk. The
sequence 5'-AAUAAA-3' forms part of the recognition site for polyadenylation
of late SV40 mRNAs. Cell 24:25l-260 (l98l).
Clarke, L., Fitzgerald-Hayes, M., Buhler, J.-M., and J. Carbon.
The structure and function of yeast centromeres. Stadler Symposium
l3: 9-24 (l98l).
Fitzgerald-Hayes, M., Buhler, J.-M., Cooper, T. G., and J. Carbon.
Isolation and subcloning analysis of functional centromere DNA
(CENll) from S. cerevisiae chromosome XI. MCB 2: 82-87 (1982).
Fitzgerald-Hayes, M., Clarke, L., and J. Carbon.
Nucleotide sequence comparisons and functional analysis of yeast
centromere DNAs. Cell 29:
Fitzgerald-Hayes, M. and J. Carbon.
Identification of DNA sequences required for mitotic stability
of centromere plasmids in yeast.
Rec. Adv. Yeast Mol. Biol.: Recomb.DNA 1: 1-17 (1982).
Bloom, K. S., Fitzgerald-Hayes, M., and J. Carbon.
Structural analysis and sequence organization of yeast centromeres.
Cold Spring Harbor Symp. Quant. Biol. 47: 1175-1185 (1983).
Fitzgerald-Hayes, M. and Carbon, J. Identification of DNA sequences required
for mitotic segregation of centromere plasmids in yeast" Fed. Proc.
42: 1798 (1983).
McGrew, J., Diehl, B., and M. Fitzgerald-Hayes.
Single base-pair mutations in centromere element III cause aberrant
chromosome segregation in S. cerevisiae. Mol. Cell. Biol. 6: 530-538
Gaudet, A. and Fitzgerald-Hayes, M. Alterations in the adenine-plus-thymine-rich
region of CEN3
Koshland, D., Rutledge, L., Fitzgerald-Hayes, M. and L. H. Hartwell.
A genetic analysis
Fitzgerald-Hayes, M. Yeast centromeres. Yeast 3: 187-200 (1987).
Saunders, M., Fitzgerald-Hayes, M. and Bloom, K. Chromatin structure of
Gaudet, A. and Fitzgerald-Hayes, M. Mutations in CEN3 cause aberrant chromosome
segregation during meiosis in S. cerevisiae. Genetics 121: 477-489 (1989).
McGrew, J., Xiao, Z. and Fitzgerald-Hayes, M. S. cerevisiae mutants
defective in chromosome segregation. Yeast 5: 271-284 (1989).
Baker, R. E., Fitzgerald-Hayes, M. and O'Brien, T. C. Purification of
the yeast centromere binding protein CP1 and a mutational analysis of
its binding site. J. Biol.Chem. 264: 10843-10850 (1989).
Gaudet, A. and Fitzgerald-Hayes, M. The function of centromeres in chromosome
segregation. In: The Eukaryotic Nucleus: Molecular Biochemistry and Macromolecular
Assemblies. P. Strauss and S. Wilson, eds. Telford Press, Caldwell, NJ.
1990, p 845-881.
Murphy, M. and Fitzgerald-Hayes, M. Cis- and trans-acting factors involved
in centromere function. Molecular Microbiology 4:329-336 (1990).
Densmore, L., Payne, W. E. and Fitzgerald-Hayes, M.
In vivo genomic footprint of a yeast centromere.
Mol. Cell. Biol. 11: 154-165 (1991).
Murphy, M., Fowlkes, D. and Fitzgerald-Hayes, M.
Analysis of centromere function in S. cerevisiae using
synthetic centromere mutants. Chromosoma. 101: 189-197 (1991).
Payne, W.E. and Fitzgerald-Hayes, M. A mutation in PLC1, a candidate phosphoinositide-specific
phospholipase C gene from yeast, causes aberrant mitotic chromosome
segregation. Mol. Cell. Biol. 13: 4351-4364 (1993).
Xiao, Z., McGrew, J.T., Schroeder, A. and Fitzgerald-Hayes, M. CSE1
and CSE2, two new genes required for accurate mitotic chromosome segregation
in S. cerevisiae. Mol. Cell. Biol. 13: 4691-4702 (1993).
Chen, X.H., Xiao, Z., and Fitzgerald-Hayes, M. SCM2, a tryptophan permease
in Saccharomyces cerevisiae, is important for cell growth. Mol. Gen. Genetics
Xiao, Z. and Fitzgerald-Hayes, M. Functional interaction between the CSE2
gene product and centromeres in S. cerevisiae. J. Mol. Biol. 248:255-263
Stoler, S., Keith, K.C., Curnick, K.E. and Fitzgerald-Hayes, M. A mutation
in CSE4, an essential gene encoding a novel chromatin-associated protein
in yeast, causes chromosome nondisjunction and cell cycle arrest at mitosis.
Genes and Development. 9:573-586 (1995).
Schroeder, A.J., Chen, X.H., Xiao, Z. and Fitzgerald-Hayes, M. Genetic
evidence for interactions between yeast importin alpha (Srp1p) and its
nuclear export factor, Cse1p. Mol.Gen.Genet. 261: 788-795 (1999).
Keith, K.C., R.E. Baker, Y. Chen, K. Harris, S. Stoler and M. Fitzgerald-Hayes.
Analysis of primary structural
determinants that distinguish the centromere-specific function of histone
variant Cse4p from histone H3. Mol. and Cell. Biol. 19:6130-6139 (1999).
Chen, Y., K.C. Keith, K. Harris, R.E. Baker, S. Stoler and M. Fitzgerald-Hayes. The N-terminus of the centromere H3-like protein Cse4p performs an essential function distinct from that of the histone fold domain. Mol. Cell Bio. 20 (18):7037-7048 (2000).
Keith, K.C. and M. Fitzgerald-Hayes. CSE4 genetically interacts with the
S. cerevisiae centromere DNA elements CDEI and CDEII but not CDEIII:
Implications for the path of the centromere DNA around a Cse4p variant
nucleosome. Genetics 156:973-981 (2000).
DeFalco, C., M. Fitzgerald-Hayes,
J.C. Layzer, S.A. Weitze, Y. Chen, K.C. Keith and S. Stoler.
Scm3p is a novel, essential yeast centromere protein that binds
to the centromere-specific H3-like protein Cse4p. (Manuscript in preparation,