snR48

ALTERNATE NAMES: None reported

LENGTH: 112 nts

PROCESS: 2'-O-methylation of rRNA

TARGET SITE(S):
25S rRNA: Gm2791, Gm2793

Guide Domains
 
Details of the guides at the Lowe Lab S. cerevisiae Methylation Guide snoRNA Database.
  Click number to see the target site in the 2D structure: 25S-2791, 25S-2793
Click number to see the approximate location of the modification site in the ribosome:25S-2791, 25S-2793

GENOMIC ORGANIZATION: Independent gene
 

SGD ORF MAP
ORFmap

GENE DISRUPTION PHENOTYPE: Viable

CORRESPONDENCES IN HUMANS AND PLANTS:
Click here and see that yeast and humans have corresponding modifications and guide snoRNAs.
Click here and see that yeast and Arabidopsis have corresponding modifications and guide snoRNAs.

PHYLOGENETIC CONSERVATION IN FUNGI:
Click here to examine conservation of the snoRNA in fungal genomes using BLAST.

RNA SEQUENCE:

   1 cauaaugaug auuucacuua uaccuauaug uuuuuucugg caucucuaau guuaggaugu
  61 gaaguuuaag uacucuccau ucaaugaaua caauuuuuga caauaucuga uu
 

YEAST GENOME DATABASE ENTRY:
Click here to view the SGD entry for this snoRNA.

REFERENCES:
Balakin, A. G., L. Smith, and M. J. Fournier. 1996. The RNA world of the nucleolus: two major families of small RNAs defined by different box elements with related functions. Cell 86:823-834.
Ni, J., and M. J. Fournier. (unpublished). In regards to 2'-O-methylation of rRNA.
Lowe, T. M., and S. R. Eddy. 1999. A computational screen for methylation guide snoRNAs in yeast. Science 283:1168-1171.
Ghazal, G., D. Ge, J. Gervais-Bird, J. Gagnon, and S. Abou Elela. 2005. Genome-wide prediction and analysis of yeast RNase III-dependent snoRNA processing signals. Mol. Cell. Biol. 25:2981-2994.


Last update: October 13, 2006 7:04 AM.
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