ALTERNATE NAMES: None reported
LENGTH: 222 nts
PROCESS: Pseudouridine formation in rRNA
TARGET SITE(S): 18S rRNA: Y999
GENOMIC ORGANIZATION: Independent gene
GENE DISRUPTION PHENOTYPE: Viable
CORRESPONDENCES IN HUMANS AND PLANTS: Click here and see that yeast and humans have corresponding modifications and guide snoRNAs.
Click here and see that yeast and Arabidopsis have corresponding modifications and guide snoRNAs.
PHYLOGENETIC CONSERVATION IN FUNGI: Click here to examine conservation of the snoRNA in fungal genomes using BLAST.
RNA SEQUENCE:
1 gaagcaaaau uacaccauga guuccuauua acgucagccu cuuuuguacu cauaaugugg 61 cuucggaugu uugaugggcg uugcuucagu gcguacggcu caugguagau uaauuauuag 121 aaagauguau cuccagcugu ugauauuaga gggggaagcc uuucucuuuc accucgccuu 181 uuuaaacacc ugauacaguu ggucaugauu cguucuacau uu
YEAST GENOME DATABASE ENTRY:Click here to view the SGD entry for this snoRNA.
REFERENCES: Balakin, A. G., L. Smith, and M. J. Fournier. 1996. The RNA world of the nucleolus: two major families of small RNAs defined by different box elements with related functions. Cell 86:823-834. Dandekar, T., and D. Tollervey. 1993. Identification and functional analysis of a novel yeast small nucleolar RNA. Nucleic Acids Res. 21:5386-5390. Balakin, A. G., G. S. Schneider, M. S. Corbett, J. Ni, and M. J. Fournier. 1993. SnR31, snR32, and snR33: three novel, non-essential snRNAs from Saccharomyces cerevisiae. Nucleic Acids Res. 21:5391-5397. Ni, J., A. L. Tien, and M. J. Fournier. 1997. Small nucleolar RNAs direct site-specific synthesis of pseudouridine in ribosomal RNA. Cell 89:565-573. Ganot, P., M. Caizergues-Ferrer, and T. Kiss. 1997. The family of box ACA small nucleolar RNAs is defined by an evolutionarily conserved secondary structure and ubiquitous sequence elements essential for RNA accumulation. Genes Dev. 11:941-956. Lafontaine, D. L., C. Bousquet-Antonelli, Y. Henry, M. Caizergues-Ferrer, and D. Tollervey. 1998. The box H + ACA snoRNAs carry Cbf5p, the putative rRNA pseudouridine synthase. Genes Dev. 12:527-537. Henras, A., Y. Henry, C. Bousquet-Antonelli, J. Noaillac-Depeyre, J. P. Gelugne, and M. Caizergues-Ferrer. 1998. Nhp2p and Nop10p are essential for the function of H/ACA snoRNPs. EMBO J. 17:7078-7090.
