Professor, Biochemistry and Molecular Biology
University of Massachusetts, Amherst
Education and Professional Experience
1994-00 Professor, Biochemistry and Molecular Biology, University of Massachusetts, Amherst
1989-92 Associate Director, Molecular and Cellular Biology Graduate Program, UMass, Amherst
1982-94 Assistant and Associate Professor, Biochemistry and Molecular Biology, UMass, Amherst
1980-82 Postdoctoral Fellow, University of California, Santa Barbara, CA (Dr. J. A. Carbon)
1975-80 Ph.D., Molecular Biology, University of Connecticut Health Center (Dr. T. E. Shenk)
1971-75 B.S., Biology and Chemistry, University of Hartford, W. Hartford, CT.
Honors and Awards
UMass Center for Teaching Award 2000-01
TEACHnology Award 2000-01
Nominated for University Distinguished Teaching Award, UMass, 1998, 1999
Mentor, Lilly Teaching Fellows Program, 1993-94
Elected Fellow, American Association for the Advancement of Science, 1990
National Institutes of Health Research Career Development Award, 1989-94
National Science Foundation Career Advancement Award, 1988-89
Founder, New England BioLabs Workshop in Molecular Biol. & Biotechnology,
Founder, Co-Dir., UMass Summer Workshop in Molecular Biol. & Biotechnology, 1986
Co-Director, Univ. of North Carolina Workshop on Chromosome Structure, 1985
Damon Runyon-Walter Winchell Postdoctoral Fellowship Award, 1980-82
Current Research Support
|-2004 NIH (GM54766) "Functional Analysis of Centromeric Chromatin in Yeast", $1,259,513 (Direct costs) M. Fitzgerald-Hayes, P.I.|
Publications: Selected Recent Articles in Peer Reviewed Journals
Payne, W.E. and Fitzgerald-Hayes, M. A mutation in PLC1, a candidate phosphoinositide-specific phospholipase C gene from yeast, causes aberrant mitotic chromosome segregation. Mol. Cell. Biol. 13: 4351-4364 (1993).
Xiao, Z., McGrew, J.T., Schroeder, A. and Fitzgerald-Hayes, M. CSE1 and CSE2, two new genes required for accurate mitotic chromosome segregation in S. cerevisiae. Mol. Cell. Biol. 13: 4691-4702 (1993).
Chen, X.H., Xiao, Z., and Fitzgerald-Hayes, M. SCM2, a tryptophan permease in Saccharomyces cerevisiae, is important for cell growth. Mol. Gen. Genetics 244:260-268 (1994).
Xiao, Z. and Fitzgerald-Hayes, M. Functional interaction between the CSE2 gene product and centromeres in S. cerevisiae. J. Mol. Biol. 248:255-263 (1995).
Stoler, S., Keith, K.C., Curnick, K.E. and Fitzgerald-Hayes, M. A mutation in CSE4, an essential gene encoding a novel chromatin-associated protein in yeast, causes chromosome nondisjunction and cell cycle arrest at mitosis. Genes and Development. 9:573-586 (1995).
Schroeder, A.J., Chen, X.H., Xiao, Z. and Fitzgerald-Hayes, M. Genetic evidence for interactions between yeast importin alpha (Srp1p) and its nuclear export factor, Cse1p. Mol.Gen.Genet.261: 788-795 (1999).
Keith, K.C., R.E. Baker, Y. Chen, K. Harris, S. Stoler and M. Fitzgerald-Hayes. Analysis of primary structural determinants that distinguish the centromere-specific function of histone variant Cse4p from histone H3. Mol. Cell. Bio.19:6130-6139 (1999).
Keith, K.C. and M. Fitzgerald-Hayes. CSE4 genetically interacts with the S. cerevisiae centromere DNA elements CDEI and CDEII but not CDEIII: Implications for the path of the centromere DNA around a Cse4p variant nucleosome. Genetics 156: 973-981 (2000).
Chen, Y., K.C. Keith, K. Harris, R.E. Baker, S. Stoler and M. Fitzgerald-Hayes. The N-terminus of the centromere H3-like protein Cse4p performs an essential function distinct from that of the histone fold domain. Mol. Cell Bio. 20 (18):7037-7048 (2000).
DeFalco, C., M. Fitzgerald-Hayes, J.C. Layzer, S.A. Weitze, Y. Chen, K.C. Keith and S. Stoler. Scm3p is a novel, essential yeast centromere protein that binds to the centromere-specific H3-like protein Cse4p. (Manuscript in preparation, 2000).