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CURRICULUM VITAE

MOLLY FITZGERALD-HAYES
Professor
Department of
Biochemistry and Molecular Biology
University of Massachusetts, Amherst
, Massachusetts 01003
(413) 545-0235 (office)
mollyfh@biochem.umass.edu


Education and Professional Experience

1971-75 B.S., Biology and Chemistry, University of Hartford, W. Hartford, CT.

1975-80 Ph.D., Molecular Biology, University of Connecticut Health Center, Farmington, CT Dr. Thomas E. Shenk, Advisor

1980-82 Postdoctoral Fellow, University of California, Santa Barbara, CA Dr. John A. Carbon, Sponsor

1982-94 Assistant and Associate Professor, Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA

1989-92 Associate Director, Graduate Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, MA

9/96-1/97 Co-Director, Graduate Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, MA

1994-2000 Professor, Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA


Honors and Awards

UMass Center for Teaching Award 2000-01

TEACHnology Award 2000-01

Nominated for University Distinguished Teaching Award, UMass, 1998

Mentor, Lilly Teaching Fellows Program, 1993-94

Elected Fellow, American Association for the Advancement of Science, 1990

National Institutes of Health Research Career Development Award, 1989-94

National Science Foundation Career Advancement Award, 1988-89

Founder and Co-Director, New England BioLabs Summer Workshops in Molecular Biology and Biotechnology, Smith College 1986-92, Paris, France 1987-88

Co-Director, UMass Summer Workshop in Molecular Biology and Biotechnology, 1986

Co-Director, Carolina Molecular Genetics Workshop, University of North Carolina, 1985

Molecular Cellular Biology Visiting Speakers Program, Southeastern Mass. Univ., 1984

Elected Member, American Society of Biological Chemists, 1983, Sigma Xi, 1983-84

Damon Runyon-Walter Winchell Postdoctoral Fellowship, 1980-82 (Supervisor: Dr. John A. Carbon)

Connecticut Research Foundation Doctoral Dissertation Fellowship, 1979-80

Connecticut Research Found. Travel Award; Tumor Virus Meeting, England, 1979

University of Connecticut Health Center Fellowship, 1975-79

Univ.of Hartford Scholarship, 1972-75

Dana Science Scholarship, 1972-75

Alpha Chi National Honor Scholarship Society, 1975

Dr. Joseph Wenograd Research Grant, 1974


Research Support

1980-82 Damon Runyon Cancer Research Foundation, $32,000

1988-89 NSF Career Advancement Award (DBM-8809121), "Analysis of Centromere-Specific Genes in Yeast", $51,392 (total costs) M. Fitzgerald-Hayes, P.I.

1983-94 NIH (RO1 GM32257) "Yeast Centromere Structure and Function", $1,170,000 (total direct costs) M. Fitzgerald-Hayes, P.I.

1990-94 NIH (K04 GM00528) Research Career Development Award, "Analysis of Components Involved in Centromere Function", $300,000 (total costs) M. Fitzgerald-Hayes, P.I.

1994-96 Healey Endowment Grant, "Genetic Studies on the Chromosome Segregation Protein, Cse4p", $5,000 (total costs) M. Fitzgerald-Hayes, P.I.

1996-97 Faculty Research Grant, "Mutations Affecting Binding of Cse4p to H4", $5,000 (total costs) M. Fitzgerald-Hayes, P.I.

1996-2004 NIH (RO1 GM54766) "Functional Analysis of Centromeric Chromatin in Yeast", $1,259,513 (Direct costs) M. Fitzgerald-Hayes, P.I.


Invited Speaker at National Meetings

ASBC Symposium on Chromosome Structure and Gene Function, 1983

Gordon Conference on Extrachromosomal Elements, 1983 (cited in Science News, 124:12; 1983)

Gordon Conference on Biological Regulatory Mechanisms, 1984

Natíl Meeting of the Am. Society of Microbiology, Symposium on Chromosome Structure, 1988

Gordon Conference on Extrachromosomal Elements, 1989

FASEB Summer Conference on Chromosome Replication and Segregation,1990

NATO International Workshop on Chromosome Segregation & Aneuploidy, Greece, 1992

FASEB Conference on Chromosome Replication and Segregation in Yeast, Platform Session Chair: Mutational Analysis of Chromosome Stability, 1992

GSA Conference Yeast Genetics and Mol. Bio. Session Chair: Chrom. Structure and Dynamics, 1993

Gordon Conference on Segregation Elements, 1995

FASEB Conference on Chromosome Replication and Segregation in Yeast, Organizing Committee Chair, 1994, Session Chair, 1996, Invited Speaker, 1998

Gordon Conference on Plasmid and Chromosome Dynamics, Summer 1999


Publications

Fitzgerald, M. and T. Shenk.  The site at which late mRNAs are polyadenylated is altered in SV40 mutant dl882.  N.Y. Academy of  Sciences 354: 53-59 (1980).

Fitzgerald, M. and T. Shenk.  The sequence 5'-AAUAAA-3' forms part of the recognition site for polyadenylation of late SV40 mRNAs. Cell 24:25l-260 (l98l).

Clarke, L., Fitzgerald-Hayes, M., Buhler, J.-M., and J. Carbon.  The structure and function of yeast centromeres. Stadler Symposium l3: 9-24 (l98l).

Fitzgerald-Hayes, M., Buhler, J.-M., Cooper, T. G., and J. Carbon.  Isolation and subcloning analysis of functional centromere DNA (CENll) from S. cerevisiae chromosome XI. MCB 2: 82-87 (1982).

Fitzgerald-Hayes, M., Clarke, L., and J. Carbon.  Nucleotide sequence comparisons and functional analysis of yeast centromere DNAs.  Cell 29: 235-244 (1982).

Fitzgerald-Hayes, M. and J. Carbon.  Identification of DNA sequences required for mitotic stability of centromere plasmids in yeast.  Rec. Adv. Yeast Mol. Biol.: Recomb.DNA 1: 1-17 (1982).

Bloom, K. S., Fitzgerald-Hayes, M., and J. Carbon.  Structural analysis and sequence organization of yeast centromeres. Cold Spring Harbor Symp. Quant. Biol. 47: 1175-1185 (1983).

Fitzgerald-Hayes, M. and Carbon, J. Identification of DNA sequences required for mitotic segregation of centromere plasmids in yeast" Fed. Proc. 42: 1798 (1983).

McGrew, J., Diehl, B., and M. Fitzgerald-Hayes.  Single base-pair mutations in centromere element III cause aberrant chromosome segregation in S. cerevisiae. Mol. Cell. Biol. 6: 530-538 (1986).

Gaudet, A. and Fitzgerald-Hayes, M. Alterations in the adenine-plus-thymine-rich region of CEN3 affect centromere function in Saccharomyces cerevisiae. Mol. Cell. Biol. 7: 68-75 (1987).

Koshland, D., Rutledge, L., Fitzgerald-Hayes, M. and L. H. Hartwell.  A genetic analysis of dicentric minichromosomes in Saccharomyces cerevisiae. Cell 48: 801-812 (1987).

Fitzgerald-Hayes, M. Yeast centromeres. Yeast 3: 187-200 (1987).

Saunders, M., Fitzgerald-Hayes, M. and Bloom, K. Chromatin structure of altered yeast centromeres. PNAS, USA 85: 175-179 (1988).

Gaudet, A. and Fitzgerald-Hayes, M. Mutations in CEN3 cause aberrant chromosome segregation during meiosis in S. cerevisiae. Genetics 121: 477-489 (1989).

McGrew, J., Xiao, Z. and Fitzgerald-Hayes, M. S. cerevisiae mutants defective in chromosome segregation. Yeast 5: 271-284 (1989).

Baker, R. E., Fitzgerald-Hayes, M. and O'Brien, T. C. Purification of the yeast centromere binding protein CP1 and a mutational analysis of its binding site. J. Biol.Chem. 264: 10843-10850 (1989).

Gaudet, A. and Fitzgerald-Hayes, M. The function of centromeres in chromosome segregation. In: The Eukaryotic Nucleus: Molecular Biochemistry and Macromolecular Assemblies. P. Strauss and S. Wilson, eds. Telford Press, Caldwell, NJ. 1990, p 845-881.

Murphy, M. and Fitzgerald-Hayes, M. Cis- and trans-acting factors involved in centromere function. Molecular Microbiology 4:329-336 (1990).

Densmore, L., Payne, W. E. and Fitzgerald-Hayes, M.  In vivo genomic footprint of a yeast centromere.  Mol. Cell. Biol. 11: 154-165 (1991).

Murphy, M., Fowlkes, D. and Fitzgerald-Hayes, M.  Analysis of centromere function in S. cerevisiae using synthetic centromere mutants. Chromosoma. 101: 189-197 (1991).

Payne, W.E. and Fitzgerald-Hayes, M. A mutation in PLC1, a candidate phosphoinositide-specific     phospholipase C gene from yeast, causes aberrant mitotic chromosome segregation. Mol. Cell. Biol. 13: 4351-4364 (1993).

Xiao, Z., McGrew, J.T., Schroeder, A. and Fitzgerald-Hayes, M. CSE1 and CSE2, two new genes required for accurate mitotic chromosome segregation in S. cerevisiae. Mol. Cell. Biol. 13: 4691-4702 (1993).

Chen, X.H., Xiao, Z., and Fitzgerald-Hayes, M. SCM2, a tryptophan permease in Saccharomyces cerevisiae, is important for cell growth. Mol. Gen. Genetics 244:260-268 (1994).

Xiao, Z. and Fitzgerald-Hayes, M. Functional interaction between the CSE2 gene product and centromeres in S. cerevisiae. J. Mol. Biol. 248:255-263 (1995).

Stoler, S., Keith, K.C., Curnick, K.E. and Fitzgerald-Hayes, M. A mutation in CSE4, an essential gene encoding a novel chromatin-associated protein in yeast, causes chromosome nondisjunction and cell cycle arrest at mitosis. Genes and Development. 9:573-586 (1995).

Schroeder, A.J., Chen, X.H., Xiao, Z. and Fitzgerald-Hayes, M. Genetic evidence for interactions between yeast importin alpha (Srp1p) and its nuclear export factor, Cse1p. Mol.Gen.Genet. 261: 788-795 (1999).

Keith, K.C., R.E. Baker, Y. Chen, K. Harris, S. Stoler and M. Fitzgerald-Hayes. Analysis of  primary structural determinants that distinguish the centromere-specific function of histone variant Cse4p from histone H3. Mol. and Cell. Biol. 19:6130-6139 (1999).

Chen, Y., K.C. Keith, K. Harris, R.E. Baker, S. Stoler and M. Fitzgerald-Hayes. The N-terminus of the centromere H3-like protein Cse4p performs an essential function distinct from that of the histone fold domain.  Mol. Cell Bio. 20 (18):7037-7048 (2000).

Keith, K.C. and M. Fitzgerald-Hayes. CSE4 genetically interacts with the S. cerevisiae centromere DNA elements CDEI and CDEII but not CDEIII: Implications for the path of the centromere DNA around a Cse4p variant nucleosome. Genetics 156:973-981 (2000).

DeFalco, C., M. Fitzgerald-Hayes, J.C. Layzer, S.A. Weitze, Y. Chen, K.C. Keith and S. Stoler.  Scm3p is a novel, essential yeast centromere protein that binds to the centromere-specific H3-like protein Cse4p. (Manuscript in preparation, 2000).


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