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Recent Publications
2011
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Wang Q, Zhuravleva A, Gierasch LM.
Exploring weak, transient protein-protein interactions in crowded in vivo
environments by in-cell NMR spectroscopy.
Biochemistry in press (2011).
Smock RG, Blackburn ME and Gierasch LM.
The conserved, disordered C-terminus of DnaK enhances in vitro chaperone function and cellular survival upon stress. J Biol Chem 286:31821 (2011).
Zhuravleva A, Gierasch LM.
Allosteric signal transmission in the nucleotide-binding domain of 70-kDa heat shock protein (Hsp70) molecular chaperones.
PNAS 108:6987 (2011).
Gierasch LM.
A career pathway in protein folding: from model peptides to postreductionist protein science.
Protein Sci 20:783 (2011).
Krishnan B, Gierasch LM.
Dynamic local unfolding in the serpin α-1 antitrypsin provides a mechanism for loop insertion and polymerization.
Nat Struct Mol Biol 18:222 (2011).
Gierasch, LM. How One Bad Protein Spoils the Barrel: Structural Details of β(2)-Microglobulin Amyloidogenicity.
Mol Cell 41:129 (2011).
Gershenson A, Gierasch LM. Protein folding in the cell: challenges and
progress. Curr Opin Struct Biol 21:32 (2011).
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2010
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Smock RG, Rivoire O, Russ WP, Swain JF, Leibler S, Ranganathan R, Gierasch LM.
An interdomain sector mediating allostery in Hsp70 molecular chaperones.
Mol Sys Bio 6:414 (2010).
Liu Y, Gierasch LM, Bahar I.
Role of Hsp70 ATPase Domain Intrinsic Dynamics and Sequence Evolution in Enabling its Functional Interactions with NEFs.
PLoS Comp Bio 6:9 (2010).
Hong J, Gierasch LM.
Macromolecular crowding remodels the energy landscape of a protein by favoring a more compact unfolded state.
J Am Chem Soc 132:10445-52 (2010).
Clérico EM, Zhuravleva A, Smock RG, Gierasch LM.
Segmental isotopic labeling of the Hsp70 molecular chaperone DnaK using expressed protein ligation.
Biopolymers 94: 742-52 (2010).
Ghosh RP, Nikitina T, Horowitz-Scherer RA, Gierasch LM, Uversky VN, Hite K, Hansen JC, Woodcock CL.
Unique physical properties and interactions of the domains of methylated DNA binding protein 2.
Biochemistry 49: 4395-410 (2010).
Eyles SJ, Gierasch LM. Nature's molecular sponges: Small heat shock proteins grow into their
chaperone roles. PNAS 107: 2727-8 (2010).
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2009
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Gierasch LM, Gershenson A. Post-reductionist protein science, or putting Humpty Dumpty back together
again. Nat Chem Biol 5:774-7 (2009).
Hebert DN, Gierasch LM. The molecular dating game: an antibody heavy chain hangs loose with a chaperone
while waiting for its life partner. Mol Cell 34:635-6 (2009).
Clérico EM, Szymanska A, Gierasch LM. Exploring the interactions between
signal sequences and E. coli SRP by two distinct and complementary cross-linking
methods. Biopolymers 92:201-11 (2009).
Smock RG, Gierasch LM. Sending signals dynamically. Science 324: 198-203 (2009).
Ignatova Z, Gierasch LM. A Method for Direct Measurement of Protein Stability In Vivo.
Methods Mol. Biol. 490: 165-78 (2009).
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2008
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Krishnan B, Gierasch LM.
Cross-Strand Split Tetra-Cys Motifs as Structure Sensors in a β-Sheet Protein.
Chem Biol 15, 1104-15 (2008).
Ghosh RP, Horowitz-Scherer RA, Nikitina T, Gierasch LM, Woodcock CL. Rett syndrome-causing mutations in human MeCP2 result in diverse structural changes that impact folding and DNA interactions.
JBC 283, 20523-34 (2008).
Hinz J, Gierasch LM, Ignatova Z. Orthogonal Cross-Seeding: An Approach To Explore Protein Aggregates In Living Cells.
Biochemistry 47, 4196-4200 (2008).
Gierasch LM, Deber CM, Brodsky B. Celebrating the scientific legacy of Elkan R. Blout.
Biopolymers 89, 323 (2008).
Marcelino AM, Gierasch LM. Roles of β-turns in protein folding: From peptide models to protein engineering.
Biopolymers 89, 380-91 (2008).
Ignatova Z, Gierasch LM. A Fluorescent Window into Protein Folding and Aggregation in Cells.
Methods Cell Biol. 89:59-70 (2008).
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2007
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Ignatova Z, Thakur AK, Wetzel R, Gierasch LM. In-cell aggregation of a polyglutamine-containing chimera is a multi-step process initiated by the flanking sequence.
JBC 282, 36736-43 (2007).
Clérico EM, Maki JL, Gierasch LM. Use of synthetic signal sequences to explore the protein export machinery.
Biopolymers 90, 307-19 (2007).
Ignatova Z, Gierasch LM. Effects of osmolytes on protein folding and aggregation in cells.
Methods Enzymol 428, 355-72 (2007).
Swain JF, Dinler G, Sivendran R, Montgomery DL, Stotz M, Gierasch LM. Hsp70 chaperone ligands control domain association via an allosteric mechanism mediated by the interdomain linker.
Mol Cell 26, 27-39 (2007).
Gierasch LM. In memoriam: A true statesman of science, Elkan R. Blout.
Biopolymers 85, vi (2007).
Krishnan B, Szymanska A, Gierasch LM. Site-specific fluorescent labeling of poly-histidine sequences using a metal-chelating cysteine.
Chem Biol Drug Des 69, 31-40 (2007).
Ignatova Z, Krishnan B, Bombardier JP, Marcelino AM, Hong J, Gierasch LM. From the test tube to the cell: Exploring the folding and aggregation of a
beta-clam protein. Biopolymers 88, 157-63 (2007).
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