Welcome to the Gross Lab

Research in the Gross lab focuses on receptor-mediated signaling in individual cells and cell populations. The epidermal growth factor receptor (EGFR) is our main interest. Quantitative CCD imaging technology allows us to measure EGF binding, [Ca²⁺] signaling, fluorescent EGF processing, and GFP-EGFR trafficking, all in individual cells. We are particularly interested in the molecular specific interactions between the EGFR and intracellular structural elements. We are also actively working on the mode of EGF signal transduction in mammalian cumulus cells. (Cumulus cells surround the oocyte in the ovarian follicle.)